nimetazepam

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UV spectrum	Physical Properties
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UV spectrum

Retention time : 11.85min Optimum wavelength : 265nm Sensitiveness : 9.00ng Absorbance / 100ng : 0.2365 abs.sec

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Apparatus and Analysis conditions

• Mobile phase : (10mM HClO4 + 10mM NaClO470%) + (CH3CN30%)
  
• Flow-rate : 1.0mL/min.
  
• Column : FineSIL C18T (25cm x 4.0mm i.d.)
  (monomericODS, particle size 5 x 10^-6 m ) (Jasco).
  
• Wavelength : 210-350nm.
  
• Column temperature : 50c
  

• 880 PU LC pump (Jasco, Hachioji, Japan)
• System controller 801-SC
• Gradient device 880-02
• Detector MULTI-320
• Data processing system DP-L320/98(Jasco, Hachioji, Japan)
  (Time Accumulation 0.8sec.)

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Physical Properties

• Molecular Formula : C16H 13N3O3
  
• Molecular weight : 295.30
  
• Chemical name : 1-methyl-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
  
• properties : White, light yellow crystal. Non smell.
  
• melting point : 158-161c
  
• log P : 2.16 ( Experimentally determined value ) 2.21 ( Calculated value )
  
• Ionization Constant pKa : 2.63
  
• Solubility
  • Chloroform , Glacial acetic acid : easily soluble
    
  • Water, Ethanol , Ether : hardly soluble
    

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• Oral administration / 1day : 3-5mg
  
• Drug Activity Classification : Hypnotic
  

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References

• COMPREHENSIVE MEDICAL CHEMISTRY
  The Rationary Design, Mechanistic Study & Therapeutic Application of Chemical Compounds Volume 6 ( PERGAMON PRESS )
  

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Most recent update:Mar/1/1996.
e-mail: w3master@chrom.tutms.tut.ac.jp